The Leuven late life depression (L3D) study: PET-MRI biomarkers of pathological brain ageing in late-life depression: study protocol

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Depression in late life

Despite its prevalence and seriousness, depression in late life remains underappreciated as a source of disability and suffering for older people and their families. Despite a solid and substantial body of research, recognition of depression remains problematic and is often attributed to normal developmental changes in aging. Treatment efficacy data notwithstanding, the adequacy and appropriate...

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Aetiology of late-life depression

Depressive disorder has no single cause. Arguably, in old age it is a more heterogeneous condition than in earlier adult life, in both clinical presentation and causation. A broad distinction is often made between earlyand late-onset depression in later life. The aetiology of these may differ and is currently the subject of new research. Aetiology is often subdivided into risk factors (vulnerab...

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A neuropathological study of vascular factors in late-life depression.

OBJECTIVES Depression is a common psychiatric disorder in late life and it may be associated with vascular disease processes. Although there are clinical and neuroimaging studies lending support to such a "vascular depression" hypothesis there have been no neuropathological studies to directly test this. Postmortem tissue was investigated to determine whether late life depression was associated...

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Relationship between atherosclerosis and late-life depression: the Rotterdam Study.

CONTEXT Depression in late life has been associated with vascular abnormalities. Several studies have demonstrated that persons with brain infarcts are more likely to have depressive disorders. Furthermore, depression is related to the subsequent development of ischemic heart disease. OBJECTIVE To investigate the relationship between atherosclerosis at different locations and depression in th...

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ژورنال

عنوان ژورنال: BMC Psychiatry

سال: 2021

ISSN: 1471-244X

DOI: 10.1186/s12888-021-03063-y